Endoscopic management of upper urinary tract urothelial malignancies: broadening experience.

Upper urinary tract urothelial tumors reflect a small but growing number of urologic malignancies. The application of progressive endoscopic therapies including ureteroscopic and percutaneous nephroscopic resection and topical chemotherapy have found success, defined as the preservation of the renal unit without malignant progression, in those with low grade lesions. Careful and meticulous diagnostic endoscopy with tissue sampling and cytologic evaluation is key to directing treatment and counseling patients with regard to the risk of recurrence and progression. It is the population with a low grade lesion and negative cytology that are most commonly selected for endsoscopic resection. Those with high grade lesions who opt for endoscopic resection are counseled that this therapy is palliative and can often control local symptoms but is infrequently curative. Surveillance endoscopy post endoscopic resection and topical chemotherapy is essential. With growing surgical experience and improved instrumentation, the complications associated with these and other endoscopic procedures is acceptably low.